Endocrine Abstracts

Introduction: Its has been suggested that atrial natriuretic peptide (ANP) may contribuye to the development of microalbuminuria in diabetes mellitus.Plasma ANP concentration have been reported to be elevated in association with microalbuminuria, all of wich predict the future development of overt nephropathy in diabetes (1).Key players in neurohormonal activation include neuropeptides and their receptors wich include the ANP (2).<...

Introduction: Adrenal lesions occur in more than 10% of the general population. Most are benign, but 2.5% are metastatic disease to the adrenal from tumors such melanoma, renal, breast, colon and lung carcinoma. Adrenal metastatic disease is usually asymptomatic and diagnosed in the extension study or the primary tumor. However it is unusual as a presentation of an endocrine tumor or like the first manifestation of metastatic disease.We present two patie...

Objective: To compare the effects of a classic therapy to those of a novel treatment for androgen excess in adolescent girls.Study design: Randomized, open-labeled trial over 12 months.Study participants: Adolescents (n=34; mean age 16 year, BMI 23 kg/m2) with hyperinsulinemic androgen excess and without risk of pregnancy.Interventions: Ethinyl estradiol-cyproterone acetate (EE-CA; Diane 35 ...

Introduction: The onset and progression of liver damage in non-alcoholic fatty liver disease (NAFLD) is tightly associated with metabolic derangements. Steroids may affect lipid metabolism but their alterations in the setting of NAFLD remain to be fully explored.Patients and Methods: We analyzed data from 267 patients with biopsy-proven NAFLD and 112 controls (CT). A panel of 26 steroids (including glucocorticoids, mineralocorticoids, androgens, and prog...

Hyperthyroid rats and humans exhibit increased energy expenditure and marked hyperphagia. Recent evidence has pointed that alterations of thermogenesis linked to hyperthyroidism are associated to dysregulation of hypothalamic AMPK and fatty acid metabolism; however, the central mechanisms mediating hyperthyroidism-induced hyperphagia remain largely unclear.Objective: The aim of our study was to assess if alterations in feeding in hyperthyroidism are asso...